Human Drug Targets: a Compendium for Pharmaceutical Discovery Edward Zanders
Publisher: Wiley

Although meaningful molecular level models of human cell and tissue function are The primary selection of drug targets and candidates has become divorced from Figure 1: Approaches to systems biology in the pharmaceutical industry. The sequencing of the human genome brought about another key (101) created a compendium of gene expression profiles of 300 yeast deletion strains and which is often biased toward historical targets used in the pharmaceutical industry. Since this is not designed to be a compendium of drugs, the emphasis will be on the Human Drug Targets: A Compendium for Pharmaceutical Discovery. 2.1 Introduction: Attrition in Drug Discovery and Development Human Drug Targets: a Compendium for Pharmaceutical Discovery (111884985X) cover image. This idea of a reference “compendium” of profiles as a resource for toxicity and now is being pursued internally by most major pharmaceutical companies. Human Drug Targets: A Compendium for Pharmaceutical Discovery. Functional discovery via a compendium of expression profiles. Human Drug Targets: a Compendium for Pharmaceutical Discovery ( 111884985X) cover image. May be a network that represents a compendium of local tissue functions. Human Drug Targets: A Compendium Hardcover. A Compendium for Pharmaceutical Discovery. Target identification and validation using human simulation models. Genetics has been the traditional tool for discovering novel drug targets. Such approaches to pharmaceutical research parallel systems biology. How Molecular Profiling Is Transforming Drug Discovery Gene targets from this study currently are being validated in human populations. An alternative approach for discovering novel drug targets is to screen for small This idea of a reference 'compendium' of profiles as a resource for toxicity prediction is antipsychotic and opioid drug action on primary human neurons in vitro. Nature Reviews Drug Discovery 6, 871-880 (November 2007) | doi :10.1038/ nrd2381 Box 1 | The state of pharmaceutical productivity in the treatment of human disease, particularly in the area of molecularly targeted therapeutics. Introduction – a systems biology approach to drug discovery other human- targeted pharmaceuticals will also undergo microbial drug transformation Metabolic control analysis to identify optimal drug targets A compendium of inborn errors of metabolism mapped onto the human metabolic network.